07.00 - 08.30 - Breakfast

 

08.45 - Symposium 6
 

MEIOSIS, GENETICS & EVOLUTION

Chairpersons: Jörg Gromoll, Anne Goriely & Frank Tüttelmann

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08.45 - 09.15 - Frederic Chalmel - Spermatogenesis in modern humans: How did we succeed our hybrid speciation?

09.15 - 09.45 - James Turner - Fertile offspring from sterile sex chromosome trisomic mice

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Miniposter Session 6

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09.45 - Selected miniposters

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09.45 - 10.00 - Thomas Darde, Estelle Lecluze, Nathan Alary, Aurélie Lardenois, Olivier Collin, Frank Tüttelmann, Serge Nef, Antoine Rolland and Frédéric Chalmel - The ReproGenomics Viewer 2.0: a major update integrating features for single-cell data

10.00 - 10.15 -  Sabrina Jan, Aldo Jongejan, Cindy Korver, Saskia Van Daalen, Ans Van Pelt, Sjoerd Repping and Geert Hamer - Distinct prophase arrest mechanisms in human male meiosis

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10.15 - Coffee break

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10.45 - 11.30 - Short talks I

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Daniela Fietz, Josefine Bennien, Katharina Bakhaus, Sabine Kliesch, Florian Wagenlehner, Joachim Geyer and Martin Bergmann - Biological significance of sodium-dependent organic anion transporter SOAT in human spermatogenesis

Joachim Weitzel, Alexander Sobczak, Dirk Koczan, Martina Langhammer, Norbert Reinsch and Marten Michaelis - Testicular transcriptional signatures associated with high fertility

Sofia Winge, Marlene Dalgaard, Jacob Jensen, Kirstine Belling, John Nielsen, Niels Graem, Lise Aksglaede, Søren Brunak, Mikkel Schierup, Niels Skakkebaek, Anders Juul, Ewa Rajpert-De Meyts and Kristian Almstrup - Transcriptome profiling of Klinefelter testis tissue reveals crucial roles of somatic differentiation and long non-coding RNAs in testis development

Laura Bellutti, Leila Demini, Sophie Tourpin, Delphine Moison and Gabriel Livera - MeioD, a new conserved meiotic gene dispensable for mouse fertility

Nihan Ozturk, Sabrina Gies, Sina Kürschner, Klaus Steger, Hans Schuppe, Kai Ni, Nina Rogenhofer and Undraga Schagdarsurengin - Epigenetic regulation of LINE1 and its impact on male subfertility

Nils Van Der Bijl, Albrecht Röpke, Laura Hankamp, Sabine Kliesch and Frank Tüttelmann - Mutations in STAG3 cause autosomal-recessive male infertility due to meiotic arrest

Annalucia Darbey, Laura Milne and Lee Smith - Developing techniques to target the adult testicular somatic cells with deliverable transgenics

Agnieszka Malcher, Tomasz Stokowy, Soroosh Monem, Karolina Nowicka-Bauer, Adam Czyzyk, Piotr Jedrzejczak, Blazej Meczekalski, Natalia Rozwadowska, and Maciej Kurpisz - Genetic characterization of patients with complete androgen insensitivity syndrome (CAIS) 

 

Nina Neuhaus, Jörg Gromoll, Sabine Kliesch, Stefan Schlatt and Sandra Laurentino - Methylation profile of human spermatogonia compared to sperm and somatic cells 

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11.30 - Break

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11.50 - 12.40 - Short talks II

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Herta Ademi, Beatrice Conne, Isabelle Stevant and Serge Nef - A Wnt5aTetOn-3G knockin mouse model for steroidogenic cell lineage tracing

Jonathan Ribeiro, Cynthia Petrillo, Pauline Dupaigne, Clotilde Duquenne, Xavier Veaute, Carole Saintomé, Orestis Faklaris, Didier Busso, Raphael Guerois, Emmanuelle Martini and Gabriel Livera - MEIOB and SPATA22 ressemble RPA subunits and interact with the RPA complex to ensure meiotic recombination

Arka Baksi, Ruchi Jain, Vasan Ss, Paturu Kondaiah and Rajan Dighe - Correlation between the aberrant testicular germ cell gene expression and human male infertility

Rüdiger Behr, Drummer Charis, Vogt Edgar and Berit Neumann - Frequent silencing of a transgene in marmoset monkeys after male and female germline transmission

Tiina Lehtiniemi, Fuping Zhang, Frederic Chalmel, Jennifer Dumdie, Miles Wilkinson and Noora Kotaja - The pivotal role of the endonuclease SMG6 in the control of male germ cell transcriptome

Peter Vogt, Jutta Zimmer, Ulrike Bender, Frank Dechend, Notker Graf and Thomas Strowitzki - AZFa deletion extension in proximal Yq11 including UTY + VCY causes complete loss of all premeiotic germ cells in human male germ line

Matthias Vockel, Carolin Dreier, Sabine Kliesch, Peter Wieacker and Frank Tüttelmann - Mutational spectrum and functional relevance of the adhesion receptor ADGRG2 in X-linked CBAVD

Liina Nagirnaja, Jannette Rusch, Alexandra Lopes, Kristian Almstrup, Brendan Houston, Ewa Rajpert-De Meyts, Maris Laan, Moira O’Bryan, Kenneth Aston and Donald Conrad - GEMINI study: understanding the genetics and genomics of severe male infertility

Vyacheslav Chernykh, Maria Shtaut, Tatiana Yamandi, Natalia Safina, Aleksandr Polyakov, Liubov Kurilo, Anna Kashintsova, Victor Spangenberg and Oksana Kolomiets - Complex study of spermatogenesis abnormalities in infertile men with AZF deletions

Alexandra Lopes, Liina Nagirnaja, Filipa Carvalho, João Gonçalves, Susana Fernandes, Iris Pereira-Caetano, Kristian Almstrup, Ewa Rajpert-De Meyts, Susana Seixas, Brendan Houston, Alberto Barros, Moira O'Bryan, Kenneth Aston and Donald Conrad - Assessing the impact of copy number variation on severe spermatogenic impairment with exome data

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13.00 - Lunch

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14.15 - Symposium 7

LIFESTYLE, ENVIRONMENT, INFECTION & IMMUNITY

Chairpersons: Bernard Jégou, Jorma Toppari & Renata Tavares

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14.15 - 14.45 - Kristian Almstrup - Pubertal development - crosstalk between environment and the epigenome

14.45 - 15.15 - Romain Barrés - Sperm-mediated epigenetic inheritance in metabolic disorder

 

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Miniposter Session 7

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15.15 - Selected miniposters

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15.15 - 15.30 - Pablo Hurtado-Gonzalez, Joni Macdonald, Anne Jorgensen, Richard Anderson, Karen Kilcoyne, Richard Sharpe and Rod Mitchell - Exposure to therapeutic levels of paracetamol or ibuprofen affects germ cell development and epigenetic regulators in human fetal testis and ovary

15.30 - 15.45 - David Kristensen, Christèle Desdoits-Lethimonier, Abigail Mackey, Marlene Dalgaard, Federico De Masi, Cecilie Munkbøl, Bjarne Styrishave, Christian Platel, Anders Hay-Schmidt, Tina Jensen, Laurianne Lesné, Séverine Mazaud-Guittot, Karsten Kristiansen, Søren Brunak, Michael Kjaer, Anders Juul and Bernard Jégou - Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

 

15.45 - Coffee Break

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16.15 - 16.55 - Short talks I

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Shabnam Bakhshalizadeh, Maryam Miri, Reza Shirazi and Saeed Shokri - Efficacy of compound therapy by ginseng and ciprofloxacin on bacterial prostatitis

Anna Hejmej, Alicja Kaminska, Laura Pardyak, Sylwia Marek, Malgorzata Kotula-Balak and Barbara Bilinska - Notch signaling pathway in adult rat testis as a target for bisphenol A

Andrew Pask, Deidre Mattiske, Shawna Zhao and Melanie Stewart -Transgenerational effects of diethylstilbestrol on male germ cells

Sonia Abdallah, Delphine Moison, Juliette Borderies, Jean-Philippe Antignac, René Habert, Gabriel Livera, Virginie Rouiller-Fabre and Marie-Justine Guerquin - Fetal exposure to bisphenol A-related substitutes impair germ cell differentiation in mice

Aurore Gely-Pernot, Chunxiang Hao, Louis Legoff, Luc Multignier, Shereen D'Cruz, Christine Kervarrec, Bernard Jégou, Sergei Tevosian and Fatima Smagulova - Transgenerational effects promoted by chlordecone are mediated via histone trimethylation in a limited regions in mouse genome

Hanna Johansson, Lene Nielsen, Anne Vinggaard, Martin Bahl and Terje Svingen - Glyphosate alone does not adversely affect testicular androgen function in mature rats

Anna Rudnicka, Evdochia Adoamnei, Carrie Nielson, José Noguera-Velasco, Jaime Olivares and Alberto Torres-Cantero - Associations of vitamin D intake and vitamin D serum levels with semen quality and reproductive hormone levels in young men from southern Spain

Eliska Valaskova, Eva Zatecka, Hasmik Margaryan, Romana Bohuslavova, Katerina Dvorakova-Hortova, Gabriela Pavlinkova and Jana Peknicova - Alterations in expression of selected testicular genes and protein level in mice model of diabetes mellitus 2

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16.55 - Break

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17.15 - 17.55 - Short talks II

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Rita Rahban, Laerke Priskorn, Alfred Senn, Eric Stettler, Niels Jørgensen and Serge Nef - Poor semen quality with geographical variations in Switzerland

Katja Eubler, Carola Herrmann, Frank-Michael Köhn, Ulrich Schwarzer, Lars Kunz and Artur Mayerhofer - Ca2+ signaling and interleukin-8 secretion in human testicular peritubular cells involves the cation channel TRPV2

Nina Schmid, Lena Walenta, Astrid Tiefenbacher, Ullrich Schwarzer, Frank-Michael Koehn, Leena Strauss, Matti Poutanen and Artur Mayerhofer - NLRP3 is expressed by somatic cells of the human testis

Yoni Baert, Isabel Ruetschle, Ilka Maschmeyer, Alexandra Lorenz, Anika Oehme, Uwe Marx and Ellen Goossens - A Multi-organ-chip co-culture of human testis and liver equivalents for substance testing

Constanze Maresch, Dina Stute, Thomas Fleming, Hans-Peter Hammes and Thomas Linn - Hyperglycemia induces testicular DNA damage in type 1 diabetic Ins2Akita+/- mice via RAGE associated mechanisms

Britta Klein, Sudhanshu Bhushan, Rukmali Wijayarathna, Ralf Middendorff, Kate Loveland, Mark Hedger and Andreas Meinhardt - Bacteria themselves and/or subsequent, persistent inflammation – what may be the “crux”? Understanding the pathogenesis of epididymitis-associated subfertility

Cinthia Mendez, María Ferreiro, Lucas González, Cristian Sobarzo, Livia Lustig, Patricia Jacobo and Maria Theas - Undifferentiated spermatogonia cell cycle arrest contributes to the impairment of spermatogenesis in the testis under a chronic inflammatory process

Yongning Lu, Amir Rafiq, Monika Fijak, Joerg Klug, Trinad Chakraborty, Martin Bergmann, Andreas Meinhardt and Sudhanshu Bhushan - Necrotic cell death of Sertoli cells: a mechanism evolved by uropathogenic Escherichia coli to impair testicular function

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18.00 - 18.45 - Plenary session

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Andreas Meinhardt - The immune system of the testis: 3 infectious stories 

 

20.30 - Gala Dinner